The BRAP Monoclonal Antibody from MyBioSource.com is a Mouse Monoclonal antibody to BRAP, and BRAP2. This antibody recognizes Human antigen. The BRAP Monoclonal Antibody has been validated for the following applications: Western Blot.
Description
Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport